OECD

The Organisation for Economic Co-operation and Development (OECD) are globally recognized guidelines for safety testing and assessing the potential effects of chemicals on human health.

Update on “Guidance Document on an Integrated Approach on Testing and Assessment for Serious Eye Damage and Eye Irritation”

Organization for Economic Co-operation and Development (OECD) updated “Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation”. The updated document replaces "sequential testing strategy" with IATA for serious eye damage and eye irritation hazard identification and provides guidance on how and when to integrate existing and/or newly generated information for decision making, including decisions on the need for further testing or final decisions on classification and labelling regarding the potential eye hazard of test chemicals. The guidance document describes the elements (modules) of IATA for identification of eye hazard. It is notable that multiple testing methods developed using in vitro and ex vivo models1 allow for eye hazard classification and labeling without the need of in vivo testing (Draize test method, the US FHSA method 16CFR 1500.42, and OECD TG 405). The table below presents the strategy of Integrated Approach on Testing and Assessment for Serious Eye Damage and Eye Irritation.

OECD 431

In-Vitro Skin Corrosion: Human Skin Model Test In this method, the test material (solid or liquid) is applied to a three-dimensional human skin model and corrosive materials a...

OECD 437

Bovine Corneal Opacity and Permeability (BCOP) Test Method for Identifying Ocular Corrosives/Severe Irritants and Substances not Classified as Irritants The Bovine Corneal Opa...

OECD 439

In-Vitro Skin Irritation: Reconstructed Human Epidermis Test Method This method is based on the reconstructed human epidermis, which closely mimics the properties of the upper...

OECD 435

In Vitro Membrane Barrier Test Method for Skin Corrosion This method describes an in vitro membrane barrier test method that is used to identify corrosive substances. It utili...

OECD 492

Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labeling for eye irritation or serious eye damage Thi...